DAPT from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemDAPT
CompanyTocris Bioscience, a Bio-Techne Brand
Price Pricing Info Supplier Page View Supplier Product Page
Catalog Number2634/10
Quantity10 mg (also 50 mg)
Brand/TrademarkTocris, a Bio-Techne Brand
Purity0.99
Molecular Weight432.46
Molecule Name(2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester
FormulaC₂₃H₂₆F₂N₂O₄
StorageStore at +4°C

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionalityGliaJuly 1, 2022Sonia Sabate‐Soler et al.450‐10), 1 pg/ml TGF‐β3 (Peprotech, 100‐36E), 0.5 mM db cAMP (Sigma, D0627‐5X1G), 10 μM DAPT (R&D Systems, 2634/10) and 2.5 ng/ml Activin A (Thermo Scientific, PHC9564). Organoids were kept under static culture conditions

(2) Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunctionBrain : a journal of neurologySeptember 4, 2021Van Lent J, Verstraelen P, Asselbergh B, Adriaenssens E, Mateiu L, Verbist C, De Winter V, Eggermont K, Van Den Bosch L, De Vos WH, et al.Peprotech), glial cell derived neurotrophic factor (GDNF, 450-10, Peprotech), γ-secretase inhibitor DAPT (2634/10, Bio-Techne), ciliary neurotrophic factor (CNTF, 450-13, Peprotech) and laminin (L2020-1MG, Sigma Aldrich).

(3) Bioengineered optogenetic model of human neuromuscular junctionBiomaterialsSeptember 1, 2021Vila OF, Chavez M, Ma SP, Yeager K, Zholudeva LV, Colón-Mercado JM, Qu Y, Nash TR, Lai C, Feliciano CM, et al.0.1 μM retinoic acid at day 4; 0.5 μM SAG and 0.1 μM retinoic acid at day 7; 10μM DAPT (R&D Systems # 2634/10) at day 9; and 20 ng/ml BDNF and 10 ng/ml GDNF at day 11. 1.2. Direct differentiation of myotubes

(4) A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteinsThe EMBO journalApril 15, 2021Alderson TR, Adriaenssens E, Asselbergh B, Pritišanac I, Van Lent J, Gastall HY, Wälti MA, Louis JM, Timmerman V, Baldwin AJ, et al.(302‐79‐4, Sigma‐Aldrich), smoothened agonist (SAG, 4366/1, Bio‐Techne), γ‐secretase inhibitor (DAPT, 2634/10, Bio‐Techne), and the neurotrophic factors brain‐derived neurotrophic factor BDNF (CSB‐EL016134MO, Immunosource)

(5) Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01Cell stem cellFebruary 4, 2021Piao J, Zabierowski S, Dubose BN, Hill EJ, Navare M, Claros N, Rosen S, Ramnarine K, Horn C, Fredrickson C, et al.

(6) Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational UseCell stem cellFebruary 4, 2021Kim TW, Piao J, Koo SY, Kriks S, Chung SY, Betel D, Socci ND, Choi SJ, Zabierowski S, Dubose BN, et al.

(7) Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosisNature communicationsDecember 11, 2020Jutzi D, Campagne S, Schmidt R, Reber S, Mechtersheimer J, Gypas F, Schweingruber C, Colombo M, von Schroetter C, Loughlin FE, et al.penicillin–streptomycin, 5 µM Y-27632, 200 nM retinoic acid, 500 nM SAG, 200 µM ascorbic acid, 10 µM DAPT (Tocris, 2634), 10 ng/µl GDNF (R&D Systems, 212-GD) and 10 ng/µl BDNF (R&D Systems, 248-BDB). The medium was exchanged

(8) Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surfaceeLifeJuly 7, 2020Escamilla-Ayala AA, Sannerud R, Mondin M, Poersch K, Vermeire W, Paparelli L, Berlage C, Koenig M, Chavez-Gutierrez L, Ulbrich MH, et al.kit MycoAlert Lonza LT07-118 Mycoplasma detection kit Commercial assay or kit DAPT Tocris Bioscience 2634/10 g-secretase inhibitor Commercial assay or kit Inhibitor X Calbiochem 565771 g-secretase inhibitor Commercial assay

(9) A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and OrganoidsCell stem cellJuly 2, 2020Yang L, Han Y, Nilsson-Payant BE, Gupta V, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F, et al.

(10) In Vitro and In Vivo Development of the Human Airway at Single-Cell ResolutionDevelopmental CellApril 1, 2020Alyssa J. Miller et al.no. 236-EG-200), IFNγ (10 ng/mL, R&D Systems cat. no. CAA31639), DAPT (10 μM, R&D Systems cat. no. 2634/10), Hydrocortisone (100 ng/mL, Stem Cell Technologies cat. no. 74142). Quantification and Statistical

(11) Measurement of CD74 N-terminal Fragment Accumulation in Cells Treated with SPPL2a InhibitorBIO-PROTOCOLJune 5, 2019Ruben Martinez-Barricarte, Xiao-Fei Kong, Jean-Laurent Casanovainhibitor cocktail (Roche, catalog number: 11873580001) 32. DAPT gamma secretase inhibitor (R&D Systems, 2634/10) 33. DMSO (MP Biomedicals, catalog number: 196055) 34. 0.5 M EDTA (Fisher Scientific, catalog number:

(12) Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodiesAutophagyJune 1, 2019Haidar M, Asselbergh B, Adriaenssens E, De Winter V, Timmermans JP, Auer-Grumbach M, Juneja M, Timmerman V.factors BDNF (Immunosource, CSB-EL016134MO) and GDNF (Immunosource, 21-8506-U002), DAPT (Bio-Techne, 2634/10), LAMA/laminin (Sigma Aldrich, 114956-81-9), ROCK inhibitor, Culture One (CO) supplement (ThermoFisher Scientific

(13) Long-term functional maintenance of primary human hepatocytes in vitroScience (New York, N.Y.)April 26, 2019Xiang C, Du Y, Meng G, Soon Yi L, Sun S, Song N, Zhang X, Xiao Y, Wang J, Yi Z, et al.

(14) Quantification of human neuromuscular function through optogeneticsTheranosticsJanuary 1, 2019Vila OF, Uzel SGM, Ma SP, Williams D, Pak J, Kamm RD, Vunjak-Novakovic G.μM retinoic acid at day 4; 0.5 μM SAG and 0.1 μM retinoic acid at day 7; 10 μM DAPT (R&D Systems # 2634/10) at day 9; and 20 ng/ml BDNF and 10 ng/ml GDNF at day 11. Neurosphere dissociation. Motoneurons were

(15) Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart developmentDevelopment (Cambridge, England)November 21, 2018Gibb N, Lazic S, Yuan X, Deshwar AR, Leslie M, Wilson MD, Scott IC.or from 19 to 24 hpf. BMP and Notch signaling inhibitors dorsomorphin (Tocris 3093) and DAPT (Tocris 2634/10), respectively, were used at a concentration of 10 μM and 50 μM between 16.5 and 20 hpf. All compounds

(16) VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crushScientific reportsNovember 6, 2018Takeuchi H, Inagaki S, Morozumi W, Nakano Y, Inoue Y, Kuse Y, Mizoguchi T, Nakamura S, Funato M, Kaneko H, et al.

(17) HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neuronsNature communicationsOctober 19, 2018Kishinevsky S, Wang T, Rodina A, Chung SY, Xu C, Philip J, Taldone T, Joshi S, Alpaugh ML, Bolaender A, et al.

(18) A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenationNature communicationsOctober 2, 2018Sheng C, Jungverdorben J, Wiethoff H, Lin Q, Flitsch LJ, Eckert D, Hebisch M, Fischer J, Kesavan J, Weykopf B, et al.

(19) A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapyNature communicationsAugust 8, 2018Yang L, Chueng SD, Li Y, Patel M, Rathnam C, Dey G, Wang L, Cai L, Lee KB.

(20) The COPII cargo adapter SEC24C is essential for neuronal homeostasisThe Journal of clinical investigationAugust 1, 2018Wang B, Joo JH, Mount R, Teubner BJW, Krenzer A, Ward AL, Ichhaporia VP, Adams EJ, Khoriaty R, Peters ST, et al.

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DAPT

DAPT

DAPT

DAPT from Tocris Bioscience, a Bio-Techne Brand

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Tocris Bioscience, a Bio-Techne Brand

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DAPT from Tocris Bioscience, a Bio-Techne Brand

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